Cyclobenzaprine Flexeril vs naproxen Aleve: Side Effects, Dosage

Cyclobenzaprine is best used in short-term treatment but may be used intermittently or long-term for chronic pain. Drug interactions may change how your medications work or increase your risk for serious side effects. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

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Do not use it later for another condition unless your doctor directs you to do so. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. If you cyclobenzaprine vs flexeril notice other effects not listed above, contact your doctor or pharmacist. Drowsiness, dizziness, dry mouth, constipation, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Use of a medication taper may be warranted for chronic-use patients. This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Check with your doctor before taking any of the above while you are using this medicine.

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For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. The amount of medicine that you take depends on the strength of the medicine.

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Some mixtures of medications can lead to serious and even fatal consequences. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

naproxen

Ask your healthcare professional how you should dispose of any medicine you do not use. The dose of this medicine will be different for different patients. The following information includes only the average doses of this medicine.

At 1-week follow-up, regardless of study group, more than 50% of patients still required medication for LBP, and as shown in Table 2, many patients reported moderate or severe, and frequent pain. Despite these generally poor outcomes, more than two-thirds of patients reported that they would want to receive the same medications during a subsequent ED visit for acute LBP. The drug Cyclobenzaprine, sold under the brand Flexeril, is structurally very similar to a class of Antidepressants called Tricyclic Antidepressants. Flexeril is commonly prescribed to induce pain relief from muscle spasms and improve motor skills, sleep, and energy levels by generating pain relief. These feelings may potentially be a cause for misuse of Flexeril and lead to addictive effects. Although all skeletal muscle relaxants should be used with caution in older patients, diazepam especially should be avoided in older patients or in patients with significant cognitive or hepatic impairment.

It is also true that corticosteroids20 and acetaminophen21 are not beneficial for patients with nonradicular LBP. Whether cyclobenzaprine is superior to other drugs for the management of acute myofascial strain is unclear and it usually adds more side effects with little therapeutic gain (Turturro et al 2003). For neck pain, however, mixed results are obtained (Peloso et al 2005). There are no extensive studies on the use of cyclobenzaprine in the management of painful orofacial musculoskeletal conditions. A recent study on patients with orofacial myofascial pain compared the effect of adding therapy with clonazepam, cyclobenzaprine or placebo to a universally applied self-care and patient education programme (Herman et al 2002).

Drug Interactions between Flexeril and naproxen

Although we cannot exclude the possibility of a modest benefit of the opioid combination in a select subgroup of patients, our data do not support providing oxycodone/acetaminophen in addition to naproxen for all ED patients with acute LBP. More than 75% of participants randomized to receive naproxen used it daily and nearly two-thirds used it twice daily (Table 3). Use of additional health care resources was infrequent in the 3 study groups. Most participants did not visit their primary care clinician or a complementary/alternative medicine practitioner prior to the 1-week follow-up (Table 3).

However, we chose this study design because it more closely reflects the reality of clinical practice. Quiz Ref IDPatients were excluded for radicular pain, which we defined as pain radiating below the gluteal folds, direct trauma to the back within the previous month, pain duration for more than 2 weeks, or recent history of greater than 1 LBP episode per month. We also excluded patients who were pregnant or lactating, unavailable for follow-up, with allergy or contraindication to the investigational medications, or had chronic opioid use currently or in the past.

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